Sodium Hydroxide → 4-Amino-cinnamamide

Participants

Reaction Conditions

Reaction Steps

72 parts of 4-amino-cinnamonitrile are gradually added to 85 parts of 66° Be sulphuric acid diluted by 15 parts of water. The temperature rises of itself to 100°-105° C. It is maintained up to the end of the addition, then heated for 50 minutes at 100°-105° C., cooled to 20° C. and run on to 100 parts of water and 200 parts of ice. The product is neutralised by adding 170 parts of a 35° Be solution of sodium hydroxide, the temperature being maintained at 10°-20° C. and the solid is then filtered off and dried. 56 parts of 4-amino-cinnamamide are thus obtained. It is recrystallised from 400 parts of monochlorobenzene, M.p. 200° C.

Provenance & Evidence