反应详情

温度

0 °C

A solution of 4-chlorobenzhydryl isothiocyanate [5.2g (0.02M)] in 50 mls of dry ether at 0° C is treated with NH3 (anhyd.) for 1/2 hour while maintaining a temperature of 0° C with stirring. Stirring is continued an additional 1.5 hours at 9° to 10° C. during which time a white solid appears. The crude thiourea is filtered and washed thoroughly with ether; mp 173°-5° C. The filtrate is concentrated in vacuo to yield additional product. The combined crops of N-(4-chlorobenzhydryl) thiourea are used in the next step without further purification.

1. stirringStirring
2. filtrationThe crude thiourea is filtered
3. washwashed thoroughly with ether
4. concentrationThe filtrate is concentrated in vacuo
5. customto yield additional product
6. customThe combined crops of N-(4-chlorobenzhydryl) thiourea are used in the next step without further purification