Methyl iodide → HCID 178504034, compound

HRID 866858Notes

Reaction equation

HRID 866858 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]([NH:13][C:14]([NH2:16])=[S:15])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH3:19][I:20]>CO>[IH:20].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([NH:13][C:14]([S:15][CH3:19])=[NH:16])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 21312364N-(4-Chlorobenzhydryl)thiourea

Product 1

HCID 178504034HCID 178504034, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5.3 g (0.019 mole) of N-(4-chlorobenzhydryl)thiourea in 25 ml of methanol is treated with 2.64 g (0.019 mole) of methyl iodide and allowed to stir at room temperature overnight. The methanol is removed in vacuo to yield the crude pseudothiourea as an oil. The oily methyl N-(4-chlorobenzhydryl)carbamimidothioate hydroiodide is used in the next step without further purification.

Workup

  1. customThe methanol is removed in vacuo

Sources & evidence

ORD record
ord-9bd64a3f3ae546ed96b9ebf535ada14b
Source dataset
uspto-grants-1978_07
Patent number
US04101659

Reaction notes

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