Hydrochloric Acid → HCID 131711158, compound

Participants

Reaction Steps

In a procedure similar to that described in Example I-3, diphenylmethyl 3-formyl-7-(2-thienylacetamido)-2-cephem-4-carboxylate (104 mg) and acetylhydrazine (30 mg) are left to react in a mixture of tetrahydrofuran (8 ml) and water (1.5 ml) in the presence of hydrochloric acid (2 equivalents) at room temperature overnight to give diphenylmethyl 3-(2-acetylhydrazono)methyl-7-(2-thienylacetamido)-2-cephem-4-carboxylate (95 mg). m.p. 168-178° C (decomposition). Yield: 83%. IR: λmaxNujol 3280, 1760, 1743, 1695, 1667, 1697, 1677, 1538cm-1. UV: λmaxEtOH 301nm(ε=31700). NMR: δCDCl 3 (60MHz) 1.82s3H, 3.82s2H, 5.07d(4Hz)1H, 5.40s1H, 5.50br1H, 6.63br1H, 6.83s1H. 6.88-7.58m15-16H. [α]D23 +416° (c= 0.501, CHCl3).

Provenance & Evidence