Ammonium Chloride → HCID 20309064, compound

Participants

Reaction Steps

3-(N-Benzyl N-methylamino)-1,1-diphenyl-propan-2-one (10g.) in dry ether (250 ml.) was added to a solution of methyl magnesium iodide (from 2.4 g. magnesium and 14 2g. methyl iodide) in dry ether (250 ml.) and the mixture heated at reflux for 2 hours. Saturated ammonium chloride solution was added; isolation through ether in the usual manner gave 3-(N-benzyl,N-methylamino)-2-methyl-1,1-diphenyl-propan-2-ol, purified by chromatography on alumina using progressively graded mixtures of light petroleum and ether as eluant and isolated as the hydrochloride (6 8g., 65%), m.p. 121° - 124° (from ethanol-ether)

Provenance & Evidence