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Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | 1,1-Diphenyl-3-bromopropan-2-ol | HCID 12549067 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-Dimethylamino-1,1-diphenyl-propan-2-ol | HCID 12549122 | 75% |
反応手順
1,1-Diphenyl-3-bromopropan-2-ol (500mg.) prepared as described in Example 20 was treated with excess dimethylamine in ethanol and the solution allowed to stand overnight. Solvent was removed by evaporation and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and isolation through ether in the usual manner gave 3-dimethylamino-1,1-diphenyl-propan-2-ol (330mg, 75%) m.p. 72° - 73°
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04101676 |
| 出典データセット | uspto-grants-1978_07 |
| ORD ID | ord-53b55bb22b004e56be03f533f7f4fbff |
| 出典メモ | uspto-grants-1978_07 |