Ammonia → HCID 20319170, compound

HRID 866954Notes

Reaction equation

HRID 866954 reaction equation
[Br:1]Br.Cl.[C:4]([C:7]1[CH:8]=[CH:9][C:10]([NH2:17])=[C:11]([CH:16]=1)[CH2:12][N:13]([CH3:15])[CH3:14])(=[O:6])[CH3:5].N>C(O)(=O)C>[C:4]([C:7]1[CH:8]=[C:9]([Br:1])[C:10]([NH2:17])=[C:11]([CH:16]=1)[CH2:12][N:13]([CH3:14])[CH3:15])(=[O:6])[CH3:5]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24408BromineHCID 20318990HCID 20318990, compound

Product 1

HCID 20319170HCID 20319170, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

9.0 gm of bromine were added dropwise to a solution of 12.8 gm of 5-acetyl-2-amino-N,N-dimethyl-benzylamine hydrochloride in 100 ml of 80% acetic acid. Subsequently, the reaction mixture was made alkaline with 2 N ammonia, extracted twice with chloroform, and the organic extract was evaporated. By recrystallization of the residue from ethanol/water, 5-acetyl-2-amino-3-bromo-N,N-dimethyl-benzylamine, m.p. 92°-95° C, was obtained.

Workup

  1. extractionextracted twice with chloroform
  2. extractionthe organic extract
  3. customwas evaporated
  4. customBy recrystallization of the residue from ethanol/water, 5-acetyl-2-amino-3-bromo-N,N-dimethyl-benzylamine, m.p. 92°-95° C
  5. customwas obtained

Sources & evidence

ORD record
ord-e6cf9d897952487391a54af590c612ba
Source dataset
uspto-grants-1978_07
Patent number
US04101671

Reaction notes

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