HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → Cyanoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4-acetyl-N,N-dimethylbenzene-1-sulfonamide | HCID 2064041 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 54574074 | HCID 54574074 | — |
| Solvent | Water | HCID 962 | — |
| Product | Cyanoacetamide | HCID 7898 | — |
| Product | 3-Cyano-2-pyridone | HCID 577543 | — |
Reaction Steps
From a solution of the sodium salt of 4-(dimethylaminosulfonyl)benzoylacetaldehyde in 2 l. of water (prepared from 36.1 g. of sodium methoxide in 500 ml. of tetrahydrofuran, 49.5 g. of ethyl formate, and a solution of 137.8 g. of 4-acetyl-N,N-dimethylbenzenesulfonamide in 1.4 l. of tetrahydrofuran) and 76.6 g. of cyanoacetamide, there is obtained 6-[4-dimethylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 263°-267° C. (dec.) after crystallization from aqueous dimethylformamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04101661 |
| Source dataset | uspto-grants-1978_07 |
| ORD ID | ord-77f505c5350d46dcbfd9a1c8963a1163 |
| Source note | uspto-grants-1978_07 |