Indole → 1-(4-benzoyl-1-piperidyl)-2-(1H-indol-3-yl)ethane-1,2-dione

Participants

Reaction Steps

A sample of an indole of the formula ##STR7## in a solvent such as anhydrous ether is allowed to react with oxalyl chloride at a temperature of from -15° to 15° C. for from a couple of minutes to one hour to produce a mixture of a corresponding 3-indoleglyoxyloyl chloride in the solvent which is then added to a cooled solution of 4-benzoylpiperidine in a suitable organic solvent such as chloroform optionally containing an acid scavenger such as potassium carbonate and allowing the mixture to react at a temperature of from 15° to 40° C. for a few minutes to 12 hours to produce a 4-benzoyl-1-(indol-3-ylglyoxyloyl)piperidine of the formula ##STR8##

Provenance & Evidence