HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorobenzene → 4-(4-Chlorobenzoyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorobenzene | HCID 7964 | — |
| Reactant | 1-Acetylpiperidine-4-carbonyl chloride | HCID 100950 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 4-(4-Chlorobenzoyl)piperidine hydrochloride | HCID 2777114 | — |
Reaction Steps
By following the manipulative procedures described above in Example 1(c), and (d), 37.4 g of 1-acetylisonipecotoyl chloride, [Example 1(b)] and 40 g of aluminum chloride in 90 ml of chlorobenzene are reacted to produce 4-(4-chlorobenzoyl)piperidine hydrochloride. The salt is recrystallized thrice from an ethanol-ether mixture to give a white product, mp 233°-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04101663 |
| Source dataset | uspto-grants-1978_07 |
| ORD ID | ord-ae450d1d07b4446ea959856e92cd9c9a |
| Source note | uspto-grants-1978_07 |