HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetylpiperidine-4-carbonyl chloride → 4-(4-Methylphenyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetylpiperidine-4-carbonyl chloride | HCID 100950 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(4-Methylphenyl)piperidine hydrochloride | HCID 20351543 | — |
Reaction Steps
By following the manipulative procedures described above in Examples 1(c) and (d), 1-acetylisonipecotoyl chloride, Example 1(b), toluene, and aluminum chloride are reacted to produce 4-(4-toluyl)piperidine hydrochloride. The salt is recrystallized thrice from a methanol-ether mixture (one charcoal treatment) to give colorless needles. mp 275°-277° C., (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04101663 |
| Source dataset | uspto-grants-1978_07 |
| ORD ID | ord-4d16245276db4facaccbd39aba5c08fe |
| Source note | uspto-grants-1978_07 |