反应详情

19.1 g of 1-acetylisonipecotoyl chloride, Example 1(b) are added portionwise to a stirring suspension of 13 g of t-butylbenzene and 27 g of aluminum chloride in 175 ml of dichloroethane. The reaction mixture is refluxed for 1 hour, cooled, and poured onto ice. The organic layer is separated and the aqueous layer is extracted with chloroform. The organic layers are combined, dried, and the solvent is removed under reduced pressure leaving the oil 1-acetyl-4-(4-t-butylbenzoyl)piperidine.

1. temperatureThe reaction mixture is refluxed for 1 hour
2. temperaturecooled
3. additionpoured onto ice
4. customThe organic layer is separated
5. extractionthe aqueous layer is extracted with chloroform
6. customdried
7. customthe solvent is removed under reduced pressure