HCID 13180298, compound → HCID 20311706, compound

HRID 867028Notes

Reaction equation

HRID 867028 reaction equation
[F:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.Cl.FC1C=CC(C(C2CCN(CCCC3C4C(=CC=CC=4)NC=3)CC2)=O)=CC=1>>[F:1][C:2]1[CH:27]=[CH:26][C:5]([CH:6]([OH:7])[CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 13180298HCID 13180298, compoundHCID 13180299HCID 13180299, compound

Product 1

HCID 20311706HCID 20311706, compound

Procedure

A sample of 3-{3-[4-(4-fluorobenzoyl)piperidyl]propyl}indole, free base of Example 22, is reduced and treated by the method described in Example 2 to give 3-{3-[4-(4-fluorophenylhydroxymethyl)piperidyl]propyl}indole.

Workup

  1. additiontreated by the method

Sources & evidence

ORD record
ord-3dd9a76e60ee4c4cb056569edd66ed50
Source dataset
uspto-grants-1978_07
Patent number
US04101663

Reaction notes

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