HCID 20311696, compound → HCID 20311691, compound

HRID 867029Notes

Reaction equation

HRID 867029 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][CH:19]([C:22](=[O:30])[C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=4)[CH2:18][CH2:17]3)=[C:8]([CH3:12])[NH:9]2)=[CH:5][CH:4]=1.Cl.COC1C=C2C(C(CCCN3CCC(C(=O)C4C=CC(F)=CC=4)CC3)=C(C)N2)=CC=1>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][CH:19]([CH:22]([C:23]4[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=4)[OH:30])[CH2:18][CH2:17]3)=[C:8]([CH3:12])[NH:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 20311696HCID 20311696, compoundHCID 20311697HCID 20311697, compound

Product 1

HCID 20311691HCID 20311691, compound

Procedure

A sample of 6-methoxy-2-methyl-3-{3-[4-(4-fluorobenzoyl)piperidyl]propyl}indole, free base of Example 24, is reduced and treated by the method described in Example 2 to give 6-methoxy-2-methyl-3-{3-[4-(4-fluorophenylhydroxymethyl)piperidyl]propyl}indole.

Workup

  1. additiontreated by the method

Sources & evidence

ORD record
ord-455764d575df4ed9bceac1f73cb1e8c9
Source dataset
uspto-grants-1978_07
Patent number
US04101663

Reaction notes

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