HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridone → 3-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpiperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridone | HCID 8871 | — |
| Reactant | 3-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpyridin-4(1H)-one | HCID 12879235 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpiperidin-4-one | HCID 20317002 | — |
Reaction Steps
A 10 g. portion of 3-(3-chlorophenyl)-5-(4-chlorophenyl)-1-methyl-4(1H)-pyridinone was made from 33.6 g. of the corresponding 2-propanone by the procedures of Examples 1-3. The pyridinone was reduced with lithium aluminum hydride and the reaction mixture was separated by chromatography as described in the examples above. The products of Examples 15 and 16 were obtained as a mixture containing both, combined yield 2.1 g., m.p. 125.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04102669 |
| Source dataset | uspto-grants-1978_07 |
| ORD ID | ord-a02232f18b4043b7a675d177190285c4 |
| Source note | uspto-grants-1978_07 |