反应详情

To a solution of methoxycarbonylisocyanate (3.78 g. 0.0374 mole) in 45 ml. of dioxane is added 4-aminoveratrole (5.73 g., 0.037 mole) while maintaining a temperature of 20°-30°. After completing the addition, another 45 ml. portion of dioxane is added and the mixture then heated at reflux for a period of one hour. Evaporation of the solvent and crystallization of residual material from nitromethane provides analytically pure 1-(3,4-dimethoxyphenyl)-3-methoxycarbonylurea, m.p. 168°-170°.

1. temperaturewhile maintaining a temperature of 20°-30°
2. additionthe addition
3. temperaturethe mixture then heated
4. temperatureat reflux for a period of one hour
5. customEvaporation of the solvent and crystallization of residual material from nitromethane