Methanol → HCID 20317275, compound

Participants

Reaction Steps

To a solution of 1.7 part of 2-(2-azido-1-ethoxyethylideneamino)-5-chlorobenzophenone produced in Step (2) of Example 1 in 50 parts by volume of methanol is added a solution of 1.6 part of ammonium chloride in 5 parts by volume of water. To the mixture is added 1 part of zinc powder with stirring. After 10 minutes, the resulting precipitates are removed by filtration. The filtrate is poured into 100 parts by volume of water, and extracted with ethyl acetate. Ethyl acetate layer is washed with water and dried over anhydrous sodium sulfate. The solvent is distilled off under reduced pressure to give 7-chloro-2-ethoxy-5-phenyl-3H-1,4-benzodiazepine as an oily substance.

Provenance & Evidence