反应详情

The raw N-(1,1-dicyclopropylmethyl) N'-(βchloroethyl) thiourea obtained by step (a) is suspended in 100 ml of water and dissolved by warming. After complete solution, the aqueous phase is extracted with ether; the organic phase is discarded. The aqueous solution is made alkaline by adding an excess of 30% soda. An oily fraction separates which is then extracted with ether. The organic solution is washed with water, dried on sodium sulphate, filtered and evaporated to dryness. The cristallized residue is purified by dissolving it in the minimum amount of hot cyclohexane. By standing the solution in a cool place, 6 g of 2-(dicyclopropylmethylamino) thiazoline melting at 127°-128° C. (with decomposition) are recovered.

1. dissolutiondissolved
2. temperatureby warming
3. extractionAfter complete solution, the aqueous phase is extracted with ether
4. additionby adding an excess of 30% soda
5. extractionAn oily fraction separates which is then extracted with ether
6. washThe organic solution is washed with water
7. customdried on sodium sulphate
8. filtrationfiltered
9. customevaporated to dryness
10. customThe cristallized residue is purified
11. dissolutionby dissolving it in the minimum amount of hot cyclohexane
12. customare recovered