Methyl 7-{2-[2-(1-acetyloxycyclohexyl)ethyl]-4-oxo-3-thiazolidinyl}heptanoate → 7-{2-[2-(1-Hydroxycyclohexyl)ethyl]4-oxo-3-thiazolidinyl}heptanoic Acid

HRID 867110Notes

Reaction equation

HRID 867110 reaction equation
C([O:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH:8]1[N:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]C)=[O:20])[C:11](=[O:23])[CH2:10][S:9]1)(=O)C.C(OC1(CCC2N(CCCCCCC(OC)=O)C(=O)CS2)CCCCC1)(=O)C>>[OH:4][C:5]1([CH2:6][CH2:7][CH:8]2[N:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[C:11](=[O:23])[CH2:10][S:9]2)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 20317377Methyl 7-{2-[2-(1-acetyloxycyclohexyl)ethyl]-4-oxo-3-thiazolidinyl}heptanoateHCID 20317394Methyl 7-[2-(3-acetyloxyoctyl)-4-oxo-3-thiazolidinyl]heptanoate

Product 1

HCID 203174067-{2-[2-(1-Hydroxycyclohexyl)ethyl]4-oxo-3-thiazolidinyl}heptanoic Acid

Procedure

This compound is prepared essentially by the method as described in Example 1, Step B, except that the methyl 7-[2-(3-acetyloxyoctyl)-4-oxo-3-thiazolidinyl]heptanoate is replaced by methyl 7-{2-[2-(1-acetyloxycyclohexyl)ethyl]-4-oxo-3-thiazolidinyl}heptanoate. Chromatographic purification of the resulting product on silica gel affords the title compound as a pale yellow, viscous oil.

Workup

  1. customThis compound is prepared essentially by the method
  2. customChromatographic purification of the resulting product on silica gel

Sources & evidence

ORD record
ord-b2cbcbc7c9e148cfb2efaa5dd7de933b
Source dataset
uspto-grants-1978_07
Patent number
US04102888

Reaction notes

Loading…