methyl 6-chloro-2H-chromene-3-carboxylate → Methyl 6-chloro-3,4-dihydro-2H-1-benzopyran-3-carboxylate

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Reaction Steps

700 mg of 5B was dissolved in 75 ml of ethyl acetate and the solution was treated with hydrogen (initial pressure of 30 psig), in the presence of a 10% palladium-on-carbon catalyst, for 8 hours. The reaction mixture then was filtered and stripped of solvent to give methyl 6-chloro-3,4-dihydro-2H-1-benzopyran-3-carboxylate (5C), as a yellow liquid, boiling point not determined.

Provenance & Evidence