HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-Phenyl-3-(4-tosyloxy-benzoyl)-indolizine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Phenylindolizine | HCID 96128 | — |
| Reactant | 4-(Chlorocarbonyl)phenyl 4-methylbenzene-1-sulfonate | HCID 12390167 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 2-Phenyl-3-(4-tosyloxy-benzoyl)-indolizine | HCID 12844798 | 52.3% |
Reaction Steps
In a flask, containing a solution of 6.5g (0.044 mol) of 2-phenylindolizine in 100 ml of dichlorethane, 12.4 g (0.04 mol) of 4-tosyloxy-benzoyl chloride were added at room-temperature. The mixture was stirred for 12 hours and then poured into a 10%-solution of sodium carbonate. The product which precipitated was washed to neutrality and recrystallized from carbon tetrachloride. In this manner, 2-phenyl-3-(4-tosyloxy-benzoyl)-indolizine was obtained in a yield of 52.3%. M.P. 177°-178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04103012 |
| Source dataset | uspto-grants-1978_07 |
| ORD ID | ord-4b7bab82693540c99ededf9a5e360a7e |
| Source note | uspto-grants-1978_07 |