Isopropyl chloroformate → HCID 20317724, compound

Participants

Reaction Steps

A suspension of 2-amino-5,8-dihydro-5-oxopyrido[ 2,3-d]pyrimidine-6-carboxylic acid (1.70 g) and triethylamine (2.5 ml) in dried dimethylformamide (50 ml) was stirred at room temperature for 1 hour and to the suspension was added isopropyl chloroformate (1.90 ml) at 0°-5° C. The mixture was stirred at 5°-10° C. for one hour and a solution of N-hydroxysuccinimide (1.91 g) in dimethylformamide (20 ml) was added to it. The mixture was stirred at room temperature for 1.5 hours. The crystals precipitated were collected and washed with dichloromethane to give N-(2-amino-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carbonyloxy)succinimide (1.9 g) m.p. above 300° C.

Provenance & Evidence