Potassium Carbonate → [2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-(4-trifluoromethylbenzyl)-amine

Participants

Reaction Steps

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 4-(trifluoromethyl)benzylamine and acetonitrile essentially as described above in example 18 except that the reaction is run overnight and the compound is purified by column chromatography using a solvent gradient of 5% ethyl acetate in dichloromethane to 10% methanol in ethyl acetate. Purity by LC/MS (APCI)=98%, [M+H]+=419.

Provenance & Evidence