2-(Methylamino)ethanol → HCID 20317869, compound

Participants

Reaction Steps

To a solution of 2-methylaminoethanol (0.29 g) in ethanol (5 ml) was added a solution of 2,2-di(m-chlorophenyl)cyclopropylmethyl chloride (0.40 g) in ethanol (10 ml) at room temperature, and stirring was carried out under reflux for 10 hours. The reaction mixture was evaporated and poured into a 10 % aqueous solution of sodium hydroxide. The chloroform extract was dried and chromatographed to afford N-methyl-N-(2-hydroxyethyl)-2,2-di(m-chlorophenyl)-cyclopropylmethylamine as an oily substance. M.P. 152° - 154° C. (hydrochoride).

Provenance & Evidence