Hydrochloric Acid → HCID 70620457, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.81 g (0.01 mole) of 2-amino-2-vinyl-3-(5-imidazolyl)propionic acid in 50 ml of methanol saturated with anhydrous HCl is stirred overnight at 25° C. then evaporated to give 2-amino-2-vinyl-3-(5-imidazolyl)propionic acid methyl ester hydrochloride. The ester hydrochloride is suspended in 50 ml of methylene chloride and treated with 2.8 g (0.02 mole) of benzoyl chloride followed by treatment with 3.6 g (0.035 mole) of triethylamine. The mixture is stirred for 24 hours at 25° C., then washed with water, dried and evaporated. The residue is recrystallized from methanol to give methyl N,N'-dibenzoyl-2-amino-3-(5-imidazolyl)-2-vinylpropionate.

Provenance & Evidence