N-(2-Chloroethyl)-N-ethylaniline → 2-(N-ethylanilino)ethyl-(3-formamidopropyl)-dimethylazanium chloride

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 157 parts of N-(3-dimethylaminopropyl)formamide in 20.0 parts of water was heated to 80° C. and over a period of one and one half hours there was added 171 parts of N-ethyl-N-(2-chloroethyl)aniline. The reaction mixture was heated at 95°-100° C. until a small sample when diluted with water gave a clear solution. After about seven hours of heating at 95°-100° C. there was obtained N,N-dimethyl-N-2-(N'-ethylanilino)ethyl-N-3-formamidopropylammonium chloride in the form of an aqueous solution.

Provenance & Evidence