Piperidine → HCID 178501344, Verbindung

HRID 867297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 867297
C1CCNCC1.COC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3c(F)ccc(Br)c3C2)CN1C(=O)OC(C)(C)C>CS(C)=O.O=C(O)C(=O)Nc1c(F)cccc1F.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>COC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3c(F)ccc(N4CCCCC4)c3C2)CN1C(=O)OC(C)(C)C

Komponenten

7

Edukt 2

HCID 8082PiperidineHCID 1547282651-(tert-Butyl) 2-methyl (2S,4R)-4-((4-bromo-7-fluoroisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

Produkt 1

HCID 178501344HCID 178501344, VerbindungAusbeute 52,8 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 62657Potassium Phosphate, TribasicReagenzHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 28710784[(2,6-Difluorophenyl)carbamoyl]formic acidKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Aufarbeitung

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Quellen und Nachweise

ORD-Eintrag
ord-e6faadf0d50a45b2bef77fd6e6b74bba
Quelldatensatz
Figure 4 from Chemistry informer libraries
Originallink
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