1H-Isoindole-1,3(2H)-dione, 2-(4-chloro-2-fluoro-5-(1-methylethoxy)phenyl)-4,5,6,7-tetrahydro- → N-(2-fluoro-4 chloro-5-isopropoxyphenyl)hexahydrophthalimide

関与物質

反応手順

A pressure bottle was charged with 1.01 g (0.003 mol) of N-(2 fluoro- 4-chloro-5-isopropoxyphenyl) -3,4,5,6-tetrahydrophthalimide (see U.S. Pat. No. 4,431,822 for the preparation of this compound), 0.10 g of 5% Pt/C, and 60 ml of methylene chloride, placed on a Paar apparatus, and hydrogenated at 40 psi for 3 hours. Thin layer chromatography showed that the hydrogenation of the double bond was complete. The reaction mixture was filtered through Celite, and solvent removed from the filtrate to give 1.0 g (100% yield) of N-(2-fluoro-4 chloro-5-isopropoxyphenyl)hexahydrophthalimide as a white solid.

情報源と証拠