Tetrahydrofuran → HCID 21289667, compound

Participants

Reaction Steps

To a stirred mixture of 27.7 grams (0.17 mol) of N,N'-carbonyldiimidazole in 200 ml of dry tetrahydrofuran, which mixture was maintained at room temperature under a nitrogen atmosphere, was added a mixture of 17.4 grams(0.078 mol) of 5-[(3-pyridinyl-methyl)thio]-1,3,4-thiadiazol-2-amine (prepared by the method of Example 1) in 300 ml of dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 hour and then at reflux for 15 minutes, followed by cooling to room temperature. The reaction mixture containing the title compound was used in the subsequent reaction without isolation of this isocyanate intermediate.

Provenance & Evidence