Potassium Hydroxide → 4-Carboxy-1-(2,4-dichlorophenyl)-5-pyrazolecarboxamide

HRID 867378Notes

Reaction equation

HRID 867378 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([C:14]#[N:15])=[C:12]([C:16]([O:18]CC)=[O:17])[CH:11]=[N:10]1.[OH-:21].[K+]>C(O)C>[C:16]([C:12]1[CH:11]=[N:10][N:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[C:13]=1[C:14]([NH2:15])=[O:21])([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13772947HCID 13772947, compound

Product 1

HCID 138821304-Carboxy-1-(2,4-dichlorophenyl)-5-pyrazolecarboxamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 2.5 g. portion of ethyl 1-(2,4-dichlorophenyl)-5-cyano-4-pyrazolecarboxylate was reacted with 1 g.of potassium hydroxide in 60 ml. of 50% aqueous ethanol to obtain 1.2 g. ofpurified product, m.p. 239°-240°, with the following elemental analysis.

Sources & evidence

ORD record
ord-9d73efab39c343a6afa1c34442929938
Source dataset
uspto-grants-1988_10
Patent number
US04775409

Reaction notes

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