Potassium Hydroxide → HCID 13882131, compound

HRID 867379Notes

Reaction equation

HRID 867379 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]#[N:14])=[C:11]([C:15]([O:17]CC)=[O:16])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[OH-:20].[K+]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([NH2:14])=[O:20])=[C:11]([C:15]([OH:17])=[O:16])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13654089Ethyl 1-(4-bromophenyl)-5-cyano-1H-pyrazole-4-carboxylate

Product 1

HCID 13882131HCID 13882131, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 3.5 g. portion of ethyl 1-(4-bromophenyl)-5-cyano-4-pyrazolecarboxylate was reacted with 2.15 g. of potassium hydroxide in 50 ml. of ethanol underreflux for 2 hours to obtain 2.45 g. of the desired product, m.p. 251°-252.5°. The elemental analysis was as follows.

Sources & evidence

ORD record
ord-31014fea594e43da87a05306cabc4361
Source dataset
uspto-grants-1988_10
Patent number
US04775409

Reaction notes

Loading…