Penicillamine → HCID 2825755, compound

Participants

Reaction Steps

0.94 ml (1.07 g, 10 mmoles) of pyridine-3-aldehyde is added to a solution containing 1.5 g (10 mmoles) of D-penicillamine in 30 ml of water at room temperature while stirring. After 10 minutes, the title product begins to crystallize. The mixture is stirred for 1 additional hour, the precipitate is filtered, washed with water and dried. The thus-obtained crude product is dissolved in hot water, filtered and cooled down to give the crystalline title compound in a yield of 1.9 g (79.7%), m.p.: 164°-165° C., [α]D20 =+145° (c=0.556, dimethylsulphoxide).

Provenance & Evidence