HuagongsheHuagongshe Chemistry Print Report · For research reference only
Penicillamine → 5,5-Dimethyl-2-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridyl)-thiazolidine-4(S)-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Penicillamine | HCID 5852 | — |
| Reactant | Pyridoxal hydrochloride | HCID 6171 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5,5-Dimethyl-2-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridyl)-thiazolidine-4(S)-carboxylic acid | HCID 12795474 | — |
Reaction Steps
2.03 g (10 mmoles) of pyridoxal hydrochloride are added to a solution containing 1.50 g (10 mmoles) of D-penicillamine and 0.56 g of potassium hydroxide in 10 ml of water. After stirring for 16 hours, the precipitate is filtered out to give the title acid in a yield of 2.26 g (75.7%) which can be purified by boiling with ethanol, m.p.: 201°-202° C., [α]D25 =+68.1°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04775675 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-7f7e1dd382244f3581e33359921ed1bb |
| Source note | uspto-grants-1988_10 |