Hydrochloric Acid → HCID 15725085, compound

Participants

Reaction Steps

A solution containing 5.74 g (30 mmoles) of N-acetyl-D-penicillamine and 3.2 ml of 4-fluorobenzaldehyde in 20 ml of ether saturated with gaseous hydrogen chloride is stirred. After 5 to 6 minutes an oil separates which becomes crystalline after 30 minutes on rubbing. The precipitate is filtered out and washed with ether to give the title acid in a yield of 7.81 g (87.1%) which can be recrystallized from ethyl acetate, m.p. 144°-146° C., [α]D20 =+206.9°.

Provenance & Evidence