Acetic Anhydride → HCID 15725088, compound

Participants

Reaction Steps

5.6 ml of acetic anhydride are given to a suspension containing 2.71 g (10 mmoles) of 2-(4-chlorophenyl)-5,5-dimethylthiazolidine-4(S)-carboxylic acid in 5.6 ml of hot water and the mixture is kept at 100° C. for 8 minutes. A complete solution is obtained. On cooling, the product precipitates to give the title compound in a yield of 2.39 g (76.1%) which is recrystallized from ethanol by adding water, m.p.: 203°-205° C., [α]D22 =+111.5° (c=1.44, dimethylsulphoxide).

Provenance & Evidence