Acetic Anhydride → HCID 15725090, compound

Participants

Reaction Conditions

Reaction Steps

5.56 ml of acetic anhydride are given to a hot suspension containing 2-(2,4-dichlorophenyl)-5,5-dimethylthiazolidine-4(S)-carboxylic acid in 5.56 ml of water. The mixture is heated at 100° C. for 6 minutes, then cooled down and diluted with 10 ml of water. The crystalline precipitate is filtered to give the title compound in a yield of 2.57 g (73.8%). After recrystallization from a mixture of methanol and water, this acid melts at 233°-235° C., [α]d22 =-142.

Provenance & Evidence