Acetic Anhydride → HCID 15725086, compound

Participants

Reaction Conditions

Reaction Steps

11.2 ml of acetic anhydride are portion-wise added to a suspension containing 5.1 g (20 mmoles) of 5,5-dimethyl-2-(4-fluorophenyl)-thiazolidine-4(S)-carboxylic acid in 11.2 ml of hot water. The mixture is heated at 100° C. for 5 minutes, then cooled down. The crystals are filtered out to give the title compound in a yield of 5.83 g (98%) which is recrystallized from the mixture of ethanol and ether, m.p.: 193.5° C., [α]D22 =-96.8° (c=0.62, methanol).

Provenance & Evidence