2-Butynedioic acid → HCID 54073641, compound

HRID 867439Notes

Reaction equation

HRID 867439 reaction equation
[CH2:1]([NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[C:17]([C:22](O)=[O:23])#[C:18][C:19]([OH:21])=[O:20]>>[CH2:1]([N:7]1[C:22](=[O:23])[C:17](=[CH:18][C:19]([OH:21])=[O:20])[S:9][C:8]1=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 3712-Butynedioic acidHCID 27592821-Hexyl-3-phenyl-2-thiourea

Product 1

HCID 54073641HCID 54073641, compoundYield 64.5%

Procedure

Prepared by the method described in Example 1 from N-hexyl-N'-phenylthiourea (3.4 g, 14 mmoles) and acetylenedicarboxylic acid (1.7 g, 14 mmoles). Recrystallization from acetonitrile gave the product (3.0 g), mp 145°-146° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-1860d8d8e6274290a658efd98d161659
Source dataset
uspto-grants-1988_10
Patent number
US04775677

Reaction notes

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