反应详情

A mixture of N,N'-dicyclohexylthiourea (10.0 g, 42 mmoles) and dimethylacetylenedicarboxylate (7.8 g, 55 mmoles) in methanol (100 mls) is stirred at room temperature for 16 hours, then warmed on a steambath for 45 minutes and cooled. The precipitate is filtered off, rinsed with cold methanol and dried. This gave the product as white crystals, (11.3 g), mp 97°-98° C.

1. temperaturewarmed on a steambath for 45 minutes
2. temperaturecooled
3. filtrationThe precipitate is filtered off
4. washrinsed with cold methanol
5. customdried