N-cycloheptyl-N-methylamine → N-Cycloheptyl-N-methyl-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide

HRID 867485Notes

Reaction equation

HRID 867485 reaction equation
[CH3:1][N:2]1[C:14]2[C:5](=[N:6][C:7]3[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=O)=[CH:11][C:12]=3[CH:13]=2)[NH:4][C:3]1=[O:22].[CH3:23][NH:24][CH:25]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH:25]1([N:24]([CH3:23])[C:19](=[O:21])[CH2:18][CH2:17][CH2:16][O:15][C:10]2[CH:9]=[CH:8][C:7]3[N:6]=[C:5]4[NH:4][C:3](=[O:22])[N:2]([CH3:1])[C:14]4=[CH:13][C:12]=3[CH:11]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 276275N-cycloheptyl-N-methylamineHCID 142809914-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid

Product 1

HCID 14281010N-Cycloheptyl-N-methyl-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide

Procedure

This compound, m.p. 234.5°-236.5° C., was prepared analogous to Example 15 from 4-[(2,3-dihydro-1-methyl-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid and N-methylcycloheptylamine.

Sources & evidence

ORD record
ord-97206c5526ee4de09f9849a78dcfb0aa
Source dataset
uspto-grants-1988_10
Patent number
US04775674

Reaction notes

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