Hydrochloric Acid → HCID 14281042, compound

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A mixture of 1,3-dihydro-7-[[3-(1-methylethyl)-2-oxo-5-oxazolidinyl]methoxy]-2H-imidazo[4,5-b]quinolin-2-one (3.00 g, 8.8 mmol) and 2N sodium hydroxide solution (25 mL) was refluxed for 5.5 hours and then neutralized by addition of dilute hydrochloric acid solution. A grey solid (2.15 g, 77%) was filtered off, washed with water and air dried. Crystallization from methanol afforded 1,3-dihydro-7-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2H-imidazo[4,5-b]quinolin-2-one as a partial hydrate (1.53 g, 55%), m.p. 262°-264° C.

Provenance & Evidence