Pyridine → HCID 14257821, compound

HRID 867507Notes

Reaction equation

HRID 867507 reaction equation
[CH3:1][N:2]([C:4]([NH:6][CH3:7])=[S:5])[NH2:3].N1C=CC=CC=1.[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[C:24](Cl)=[O:25]>O>[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[C:24]([NH:3][N:2]([CH3:1])[C:4]([NH:6][CH3:7])=[S:5])=[O:25]

Participants

5

Reactant 3

HCID 1049PyridineHCID 752462-Naphthoyl chlorideHCID 30341872,4-Dimethylthiosemicarbazide

Product 1

HCID 14257821HCID 14257821, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 2,4-dimethylthiosemicarbazide (2.39 g, 2.00×10-2 mole) and pyridine (20 ml) was added dropwise 2-naphthoyl chloride. (3.89 g, 2.04×1031 2 mole) After stirring at room temperature for 48 hours the reaction was evaporated to dryness, affording a beige solid which was treated with H2O (100 ml). Filtration of the aqueous mixture gave the desired compound as a beige product, 5.47 g (100%). If pure 1-(2-naphthoyl)-2,4dimethylthiosemicarbazide is desired, the crude product is purified by crystallization.

Workup

  1. customwas evaporated to dryness
  2. customaffording a beige solid which
  3. filtrationFiltration of the aqueous mixture

Sources & evidence

ORD record
ord-8c893d5617f94fdcbb9ecca0e00aa343
Source dataset
uspto-grants-1988_10
Patent number
US04775689

Reaction notes

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