Sodium Bicarbonate → 2,4-Dimethyl-5-(naphthalen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Participants

Reaction Steps

1-(2-Naphthoyl)-2,4-dimethyl-thiosemicarbazide (5.47 g, 2.00×10-2 mole) from Example 2 and 1 molar aqueous NaHCO3 (200 ml, 2.00×10-1 mole) were stirred and warmed to reflux. After refluxing for 17 hours the reaction was allowed to cool to room temperature. The precipitate was collected by filtration, water-washed, and dried by suction. The product was crystallized from isopropyl alcohol to yield off-white, matted needles: 3.9 g (76%) mp. 173°-175° C.

Provenance & Evidence