Sodium Hydroxide → HCID 53802198, compound

Participants

Reaction Steps

14 g of the product of example 1 [(Z)/(E)isomer mixture] or of example 2 [(Z) or (E) isomer individually] are dissolved in 140 ml ethanol, combined with 70 ml 2N NaOH and heated for 3 hours under reflux. The obtained solution is evaporated down to 1/3 volume and poured onto 250 ml ice water. The aqueous phase is adjusted to pH 1 by addition of 4N HCl and the obtained precipitate filtered off, washed with H2O and dried to yield the title compound.

Provenance & Evidence