HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 12395633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6,7-Dichloro-2-cyclopentyl-5-hydroxy-2-methylindan-1-one | HCID 12395588 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 12395633 | HCID 12395633 | 83.8% |
Reaction Steps
A mixture of 6,7-dichloro-2-cyclopentyl-5-hydroxy-2-methyl-2,3-dihydro-1H-inden-1-one (9.0 g, 30 mmole), chloroacetonitrile (2.5 g, 33 mmole), potassium carbonate (4.15 g), and potassium iodide (0.5 g) in acetone (150 ml) was stirred at reflux for 19 hours. Concentration to dryness in vacuo yielded an oil that crystallized upon trituration with water. Recrystallization from benzene-cyclohexane (ca. 1:3 by volume) gave the title compound (8.5 g), m.p. 129°-131°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04775695 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-2fd8de26de934d05abf8f90b88a7e8f3 |
| Source note | uspto-grants-1988_10 |