Ammonium Chloride → HCID 70411965, compound

Participants

Reaction Steps

Sodium metal (0.1 g, 4 mg-atom) was added to methanol (50 ml) to form a solution of sodium methoxide. To this solution was added [(2-cyclopentyl-6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)amino]acetonitrile (3.37 g, 10 mmole; see Example 3), and the mixture was stirred for one hour at room temperature. Ammonium chloride (0.6 g, 11 mmole) was added and the mixture was stirred for 16 hours. The mixture was concentrated to dryness in vacuo, and the resultant residue was triturated with boiling benzene, then collected by filtration. The solid was dissolved in ethanol and the resultant solution was diluted with diethyl ether. The precipitate that formed was collected by filtration and dried to yield the title compound.

Provenance & Evidence