Ammonia → 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide

Participants

Reaction Steps

15 g (46.1 mmol) of 1-[[8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3-yl]carbonyl]imidazole are suspended in 75 ml of N,N-dimethylformamide, whereupon the suspension is treated with 7.8 ml (102 mmol) of a 25 percent aqueous ammonia solution, the mixture is stirred at room temperature for 0.75 hour and then poured into 300 ml of water. The product is filtered off under suction after 1 hour, rinsed with water and dried at 85° in a vacuum drying oven. There is obtained 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide of melting point 272°-273°.

Provenance & Evidence