Ammonia → (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxamide

Participants

Reaction Steps

A suspension of 8.8 g (21.3 mmol) of 1-[[(S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-1-yl]carbonyl]imidazole in 20 ml of N,N-dimethylformamide is treated with 3.6 ml (about 47 mmol) of a 25 percent aqueous ammonia solution and the mixture is stirred at room temperature for 1 hour. The mixture is then poured into 100 ml of water, the product is filtered off under suction after 15 minutes, rinsed with water and dried at 80° in a high vacuum. There is obtained (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxamide of decomposition point 296°.

Provenance & Evidence