Ammonia → HCID 54277046, compound

Participants

Reaction Steps

20 g (57 mmol) of 1-[[(S)-7-fluoro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-1-yl]carbonyl]imidazole are suspended in 55 ml of N,N-dimethylformamide, the suspension is treated with 9.9 ml of 25 percent ammonia solution in water, the mixture is stirred for a half hour and then poured into 300 ml of water. The precipitated product is filtered off under suction, washed with water and dried at 80° for 48 hours in a water-jet vacuum. There is obtained (S)-7-fluoro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxamide of melting point 239°-240°.

Provenance & Evidence