反应详情

温度

0 °C

Trans and cis-3-(1-aminoethyl)-4-(2'-acetoxyethyl)-2-azetidinone (0.6575 g, 0.00328 mole) is dissolved in 10 ml CH2Cl2, cooled to 0° C., and treated with 1.1 mole each of pyridine and o-nitrobenzyl chloroformate. The reaction mixture is stirred at 0° for 20 min, the ice bath is removed and stirring continued for another 30 min. The solution is diluted with CH2Cl2, washed with H2O, dried and evaporated in vacuo. Column chromatography ##STR207## of the residue gives 0.7790 g (0.00206 mole, 63% yield) of the product.

1. customthe ice bath is removed
2. stirringstirring
3. waitcontinued for another 30 min
4. additionThe solution is diluted with CH2Cl2
5. washwashed with H2O
6. customdried
7. customevaporated in vacuo